FIRST COPY LIST FAT BITCH: KILLING THE WILLPOWER MYTH RELEASES OCTOBER 15, 2026
UNLIT PUBLISHING • 2026
GLP-1 Side Effects

Depression and Low Mood

Worsening mood or loss of interest in life.

If you are having thoughts of suicide or self-harm, you do not have to work through this page first. In the US and Canada, call or text 988 (Suicide & Crisis Lifeline). If you are in immediate danger, go to the emergency room.

Why it happens

Depression and losing interest in things you usually enjoy can happen during the rewiring of our brain. Remember: for years, food was your primary dopamine hit. When the medicine mutes that “reward,” your brain might feel a little flat, as if the color has been drained from the room.

How to prevent it

We are going to work on building healthy happiness habits that increase not only dopamine, but also oxytocin, serotonin, and endorphins, which regulate the brain and create healthy channels to improve mood.

How to treat it

This isn't just “in your head”, it’s a neurochemical shift. This is why we are building our “Joy List” and seeing a therapist. We are going to treat mood changes proactively with therapy and counseling.

When to call a doctor

If mood changes interfere with daily activities, or if you have thoughts of self-harm or worthlessness, call your doctor.

When to go to the ER

  • Inability to swallow or breathe.
  • Severe, persistent vomiting (dehydration).
  • Severe abdominal pain that makes you curl into a ball.
  • Thoughts of self-harm or suicide.
  • If you feel like you are having a medical emergency.
Source: this entry is drawn from “Side Effects” in FAT BITCH: Killing the Willpower Myth by Cat Clark (UNLIT Publishing, October 15, 2026). The full chapter has the context this page does not. Get on The First Copy List and we send the order link the day it goes live.

None of this is medical advice. It is educational material drawn from FAT BITCH: Killing the Willpower Myth by Cat Clark, and it does not replace your prescriber, your pharmacist, or your actual doctor. If something here does not match what your care team told you, go with your care team and bring this along to the conversation.